*Chemotherapy that will be used for at least two months after starting Aranesp®.

Aranesp® (darbepoetin alfa) Indication

Aranesp® is used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease in patients on dialysis and not on dialysis.

Aranesp® is used to treat a lower than normal number of red blood cells (anemia) caused by chemotherapy that will be used for at least two months after starting Aranesp®.

Aranesp® should not be used for the treatment of anemia:

Aranesp® has not been proven to improve quality of life, fatigue, or well-being.

IMPORTANT SAFETY INFORMATION

Aranesp® may cause serious side effects that can lead to death, including:

For people with cancer:

For all people who take Aranesp®, including people with cancer or chronic kidney disease:

If you decide to take Aranesp®, your healthcare provider should prescribe the smallest dose that is necessary to reduce your chance of needing RBC transfusions.

If your hemoglobin level stays too high or goes up too quickly, this may lead to serious health problems which may result in death. These serious health problems may happen if you take Aranesp®, even if you do not have an increase in your hemoglobin level.

Do not take Aranesp® if you:

Before taking Aranesp®, tell your doctor if you: have heart disease; have high blood pressure; have had a seizure or stroke; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed.

If you know you are allergic to latex, talk to your healthcare provider before using Aranesp® because the needle cover on the prefilled syringe contains latex.

Aranesp® may cause other serious side effects:

Common side effects of Aranesp® include:

These are not all of the possible side effects of Aranesp®. Tell your healthcare provider about any side effects that bother you or do not go away.

You are encouraged to report negative side effects of prescription drugs to the US Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call
1-800-FDA-1088.



Please see Full Prescribing Information, including Boxed WARNINGS, and Medication Guide.